This article will discuss the research linking peptides to age-related cognitive impairment. We’ll look into current scientific studies that focus on the potential for repairing and sustaining cognitive capacities, and investigate the role of peptides in potentially preventing cognitive decline and more.
Mental Decline
Cognitive processes encompass such actions as an organism’s ability to perceive, analyze, comprehend, recall, and convey information. These functions also allow for focus and memory functions, as well as communication, higher-order thinking, and problem solving. Normal cognitive function changes may lead to cognitive deterioration with age. There are several ways in which aging affects brain function. Deterioration in cognitive abilities such as reaction time, focus, working memory, and episodic memory are hallmarks of neurological decline.
Memory loss, inability to focus or multitask, inability to solve problems, disorientation in familiar environments, and difficulties making decisions or using judgment are all symptoms commonly associated with cognitive decline.
Age-related brain structure and function changes, such as decreased blood flow and neurochemical abnormalities, are key factors. Long-term diseases may also negatively affect brain health, including diabetes, increased blood pressure, and cardiovascular disease.
Thymosin Beta-4 Peptide
Studies suggest that the possible physiological roles of the naturally occurring compound Thymosin beta 4 (T4) are tissue repair, inflammation control, and neuroprotection. The brain and other organs need to repair and regenerate tissue after injury.
T4 has been suggested to protect neurons and improve their survival and function in laboratory and animal investigations. Several mechanisms have been hypothesized for T4’s neuroprotective impact, although their precise nature is currently being investigated.
T4 has been speculated to exhibit anti-inflammatory properties by lowering inflammatory cell activation and regulating cytokine production that promotes inflammation. Neuroinflammation has been linked to many neurological illnesses. Research suggests that T4 may help preserve neurons by reducing inflammation to safe levels.
It has been purported that T4’s possible regenerative effects might increase cell survival and blood vessel development. These properties are believed to aid in repairing and regenerating tissues, including the brain. Findings imply that T4 may help maintain or restore brain function by increasing the number of surviving neurons and their connections to one another.
Antioxidant levels: Neuronal damage and cognitive decline might result from oxidative stress, which is caused when there is an imbalance between the creation of reactive oxygen species (ROS) and the capability of cells to neutralize them. Data suggests that T4 may possess antioxidant characteristics, which it may use to lower oxidative stress and protect neurons from harm.
Humanin Peptide
Humanin is a short peptide encoded by a mtORF in the 16S ribosomal RNA gene in the mitochondria. Its potential neuroprotective qualities, especially in the context of neurodegenerative illnesses, piqued scientific attention when initial research findings suggested the peptide’s possible involvement in preventing cells from apoptosis (programmed cell death).
Humanin has been suggested to have neuroprotective properties; however, the exact mechanism by which this may occur is still being studied.
Inhibition of programmed cell death is believed to be one of Humanin’s purported anti-apoptotic characteristics. This may be initiated by blocking certain apoptotic pathways and apoptosis-inducing factors. Studies suggest that Humanin’s potential ability to inhibit programmed cell death (apoptosis) may be useful in neurodegenerative research, since neuronal failure is a hallmark of neurodegenerative disorders.
Humanin has been speculated to have protective effects on mitochondria, the cellular organelles responsible for generating cellular energy and regulating the cell’s survival ability. By decreasing oxidative stress, increasing ATP generation, and blocking mitochondrial malfunction, Humanin may potentially support mitochondrial health. The preservation of energy metabolism and the prevention of cellular damage may result from neuroprotection afforded to mitochondria.
Cognitive enhancement by reducing inflammation: long-term inflammation has been linked to the development of certain forms of neurodegeneration. By hindering the generation of pro-inflammatory cytokines and regulating inflammatory signaling pathways, Humanin has been hypothesized to have anti-inflammatory properties. Humanin’s potential to reduce neuroinflammation suggests it might save brain cells from inflammatory damage.
Conclusion
In conclusion, there have been encouraging findings from research into peptides and their possible involvement in cognitive loss prevention studies. Cerebrolysin, Humanin, and Thymosin beta 4 are just a few of the peptides that have stood out as promising study subjects in this field.
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References
[i] Wang M, Feng LR, Li ZL, Ma KG, Chang KW, Chen XL, Yang PB, Ji SF, Ma YB, Han H, Ruganzua JB, Yang WN, Qian YH. Thymosin β4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-κB signaling axis in APP/PS1 mice. J Neuroinflammation. 2021 Jun 28;18(1):146. doi: 10.1186/s12974-021-02166-3. PMID: 34183019; PMCID: PMC8240373.
[ii] Rabin LA, Smart CM, Amariglio RE. Subjective Cognitive Decline in Preclinical Alzheimer’s Disease. Annu Rev Clin Psychol. 2017 May 8;13:369-396. doi: 10.1146/annurev-clinpsy-032816-045136. PMID: 28482688.
[iii] Bellia C, Lombardo M, Meloni M, Della-Morte D, Bellia A, Lauro D. Diabetes and cognitive decline. Adv Clin Chem. 2022;108:37-71. doi: 10.1016/bs.acc.2021.07.006. Epub 2021 Aug 23. PMID: 35659061.
[iv] Yen K, Wan J, Mehta HH, Miller B, Christensen A, Levine ME, Salomon MP, Brandhorst S, Xiao J, Kim SJ, Navarrete G, Campo D, Harry GJ, Longo V, Pike CJ, Mack WJ, Hodis HN, Crimmins EM, Cohen P. Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans. Sci Rep. 2018 Sep 21;8(1):14212. doi: 10.1038/s41598-018-32616-7. PMID: 30242290; PMCID: PMC6154958.
[v] Zhang W, Zhang W, Li Z, Hao J, Zhang Z, Liu L, Mao N, Miao J, Zhang L. S14G-humanin improves cognitive deficits and reduces amyloid pathology in the middle-aged APPswe/PS1dE9 mice. Pharmacol Biochem Behav. 2012 Jan;100(3):361-9. doi: 10.1016/j.pbb.2011.09.012. Epub 2011 Oct 2. PMID: 21993310.
[vi] Kim SJ, Miller B, Kumagai H, Silverstein AR, Flores M, Yen K. Mitochondrial-derived peptides in aging and age-related diseases. Geroscience. 2021 Jun;43(3):1113-1121. doi: 10.1007/s11357-020-00262-5. Epub 2020 Sep 10. PMID: 32910336; PMCID: PMC8190245.
